Transgenic rabbits - mammary gland as a target of the transgene

Abstract

The mammary gland is the most promising target tissue because it produces large amounts of recombinant human proteins, enzymes, hormones and growth factors in a temperature-regulated fluid that may be collected daily, in a non-invasive fashion. Different observations and conclusions have been made concerning the development, histology and ultrastructure of transgenic mammary epithelium. Therefore, there is a necessity to examine possible histological and ultrastructural changes in transgenic rabbit mammary gland tissue. This review summarizes recent results based on the analyses of transgenic rabbit mammary gland at different developmental stages over four generations of transgenic animals.