Cadmium and selenium in animal tissues and their interactions after an experimental administration to rats

Abstract

The aim of this work was to find the cadmium and selenium accumulation in the experimental rat tissues and their interactions in relation to their accumulation in the animal tissues. Male rats were dosed with Cd (2 mg.kg-1 b.w., i.p. and 30 mg.l-1, p.o. in drinking water) and Se (2 mg.kg-1 b.w., i.p. and 5 mg.l-1, p.o. in drinking water). Thirty six hours after an i.p. and after 90 days of p.o. administration of Cd and Se, the sample of liver, kidney, adipose tissue and muscle tissue (m. quadriceps femoris) were collected and contents of Cd and Se were analyzed using ETAAS (Cd) and HG-AAS (Se) methods. After an i.p. administration of Cd, a significant increase in Cd (P<0.0001) and Se (P<0.01) in liver, Cd (P<0.05) in kidney and adipose tissue and Cd (P<0.0001) and Se (P<0.01) contents in muscle tissue were found. After the peroral Cd administration, an increase in Cd (P<0.0001) in liver, Cd and Se (P<0.0001) in kidney, Se in adipose tissue (P<0.05) and in muscle tissue (P<0.0001) contents were observed. After an intraperitoneal administration of Se, the increase in Se in liver and kidney (P<0.0001), in muscle (P<0.05) and the decrease in kidney Cd contents (P<0.0001) were found. After the peroral administration of Se, the significant increase in Se in liver, kidney, adipose tissue (P<0.0001) and in muscle (P<0.01) contents were recorded. The results suggest that the separate administration of Cd causes the increase in Se content in tissues and also Se administration results in decrease in Cd kidney content.