Cytogenetic studies of mesenchymal stem cells in rabbit: A mini-review
Keywords:
stem cell, chromosome, rabbitAbstract
The aim of the present review is to summarize current knowledges of in vitro studies, focused on the determination of rabbit stem cells of different origin, based on their cytogenetic examination. Stem cells represent valuable model to study the biological traits or processes of health and targeted tissues, affected by various internal or external detrimental factors. Furthermore, these cells provide a promising mechanism of treatment of existing human or animal diseases. Although recent knowledges based on serious in vitro studies bring positive promises, there are still remained a lot of issues focused to the safety of stem cell usage in the context of their clinical application. In this way, the stability of the genome across individual generations of passaged cells plays an important role, evaluated on the basis of chromosomal profile, including aneuploidy and structural studies. In the given context, various culture conditions and manipulations among the studies play a crucial role in the definition of the final chromosomal status. Up to date, there are numbers of reliable animal models used as donors of embryonic or somatic stem cells. In this way, the rabbit represents an available source with numerous advantages for cytogenetic analysis.
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